research advances
Synopses of important developments in the field of structural biology and structural genomics, including advances from the Protein Structure Initiative. The featured articles and technical highlights are specially written for the Structural Biology Knowledgebase, while the research highlights are taken from NPG publications.
February 2012
featured articles
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Buena VISTA
A novel immunoglobulin ligand with functions in autoimmunity and cancer surveillance is characterized.
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Anchoring's the way
New insights into the regulation of AQP0 reveal mechanisms involved in cataract development.
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research highlights
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Cell signaling: Crystallizing WNT signalingThree recent papers provide structural insight into the DKK1-mediated inhibition of WNT signalling.
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Structural basis of silencingThe crystal structure of the BAH domain of Sir3 in complex with the nucleosome core particle provides insight into how Sir3 can promote chromatin silencing.
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technical highlights
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Metal mates
Experimental validation of a designed metal-mediated dimer highlights the potential of computational methods.
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Overexpressed problems
An analysis of the effects of protein overexpression gives insight into the difficulties of preparing intramembrane proteins for crystallization.
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