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Structure & function 2010

  • Single-particle cryoelectron microscopy analysis reveals the HIV-1 spike as a tripod structure

    Wu S-R., Loving R., Lindqvist B., Hebert H., Koeck PJB., Sjoberg Mathilda., Garoff H

    PNAS 107, 18844-18849 (2010)

    [doi: http://dx.doi.org/10.1073/pnas.1007227107]

  • Crystal structure of Spot 14, a modulator of fatty acid synthesis

    Colbert CL., Kim C-W., Moon Y-A., Henry L., Palnitkar M., McKean WB., Fitzgerald K., Deisenhofer J., Horton JD., Kwon HJ

    PNAS 107, 18820-18825 (2010)

    [doi: http://dx.doi.org/10.1073/pnas.1012736107]

  • Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers

    Feld G.K., Thoren K.L., Kintzer A.F., Sterling H.J., Tang I.I., Greenberg S.G., Williams E.R., Krantz B.A.

    Nat Struct Mol Biol 17, 1383 - 1390 (2010)

    [doi: http://dx.doi.org/10.1038/nsmb.1923]

  • Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel

    Hilf R.J.C., Bertozzi C., Zimmermann I., Reiter A., Trauner D., Dutzler R.

    Nat Struct Mol Biol 17, 1330 - 1336 (2010)

    [doi: http://dx.doi.org/10.1038/nsmb.1933]

  • Insights into Egg Coat Assembly and Egg-Sperm Interaction from the X-Ray Structure of Full-Length ZP3

    Han L., Monne M., Okumura H., Schwend T., Cherry AL., Flot D., Matsuda T., Jovine L

    Cell 143, 404-415 (2010)

    [doi: http://dx.doi.org/10.1016/j.cell.2010.09.041]

  • Structure of a Eukaryotic CLC Transporter Defines an Intermediate State in the Transport Cycle

    Feng L., Campbell EB., Hsiung Y., MacKinnon R.

    Science 330(6004), 635-641 (2010)

    [doi: http://dx.doi.org/10.1126/science.1195230]

  • Homologue structure of the SLAC1 anion channel for closing stomata in leaves

    Chen Y.H., Hu L., Punta M., Bruni R., Hillerich B.

    Nature 467, 1074 - 1080 (2010)

    [doi: http://dx.doi.org/10.1038/nature09487]

  • NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1

    Guttler T., Madl T., Neumann P., Deichsel D., Corsini L., Monecke T., Ficner R., Sattler M., Gorlich D.

    Nat Struct Mol Biol 17, 1367 - 1376 (2010)

    [doi: http://dx.doi.org/10.1038/nsmb.1931]

  • Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes

    Arnett K.L., Hass M., McArthur D.G., Ilagan M.X.G., Aster J.C., Kopan R., Blacklow S.C.

    Nat Struct Mol Biol 17, 1312 - 1317 (2010)

    [doi: http://dx.doi.org/10.1038/nsmb.1938]

  • Structural basis for cooperative RNA binding and export complex assembly by HIV Rev

    Daugherty M.D., Liu B., Savchenko A., Parkinson J., Frankel A.D.

    Nat Struct Mol Biol 17, 1337 - 1342 (2010)

    [doi: http://dx.doi.org/10.1038/nsmb.1902]

  • Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation

    Wang T., Darwin K.H., Li H.

    Nat Struct Mol Biol 17, 1352 - 1357 (2010)

    [doi: http://dx.doi.org/10.1038/nsmb.1918]

  • The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu

    Das D., Finn R.D., Abdubek P., Astakhova T., Axelrod H.L.

    Protein Sci 19, 2131 - 2140 (2010)

    [doi: http://dx.doi.org/10.1002/pro.497]

  • The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

    Wang L., Yang J.K., Kabaleeswaran V., Rice A.J., Cruz A.C., Park A.Y., Yin Q., Damko E., Jang S.B., Raunser S., Robinson C.V., Siegel R.M., Walz T., Wu H.

    Nat Struct Mol Biol 17, 1324 - 1329 (2010)

    [doi: http://dx.doi.org/10.1038/nsmb.1920]

  • Structure of the Dom34-Hbs1 complex and implications for no-go decay

    Chen L., Muhlrad D., Hauryliuk V., Cheng Z., Lim M. et al.

    Nat Struct Mol Biol 17, 1233 - 1240 (2010)

    [doi: http://dx.doi.org/10.1038/nsmb.1922]

  • Novel α-glucosidase from human gut microbiome: substrate specificities and their switch

    Tan K., Tesar C., Wilton R., Keigher L., Babnigg G. et al.

    FASEB J 24, 3939 - 3949 (2010)

    [doi: http://dx.doi.org/10.1096/fj.10-156257]

  • Structural basis for semaphorin signalling through the plexin receptor

    Nogi T., Yasui N., Mihara E., Matsunaga Y., Noda M., Yamashita N., Toyofuku T., Uchiyama S., Goshima Y., Kumanogoh A., Takagi J

    Nature 467, 1123-1127 (2010)

    [doi: http://dx.doi.org/10.1038/nature09473]

  • Structural basis of semaphorin-plexin signalling

    Janssen BJC., Robinson RA., Perez-Branguli F., Bell CH., Mitchell KJ., Siebold C., Jones EY

    Nature 467, 1118-1122 (2010)

    [doi: http://dx.doi.org/10.1038/nature09468]

  • Structural insight into the mechanism of c-di-GMP hydrolysis by EAL domain phosphodiesterases

    Tchigvintsev A., Xu X., Singer A., Chang C., Brown G.

    J Mol Biol. 402, 524 - 538 (2010)

    [doi: http://dx.doi.org/10.1016/j.jmb.2010.07.050]

  • Structural Basis for Substrate Placement by an Archaeal Box C/D Ribonucleoprotein Particle

    Xue S., Wang R., Yang F., Terns R., Terns M. et al.

    Molecular Cell 39, 939 - 949 (2010)

    [doi: http://dx.doi.org/10.1016/j.molcel.2010.08.022]

  • Structure of a cation-bound multidrug and toxic compound extrusion transporter

    He X., Szewczyk P., Karyakin A., Evin M., Hong W-X., Zhang Q., Chang G

    Nature 467, 991-994 (2010)

    [doi: http://dx.doi.org/10.1038/nature09408]

  • Structural basis for 16S ribosomal RNA cleavage by the cytotoxic domain of colicin E3

    Ng C., Lang K., Meenan N., Sharma A., Kelley A. et al.

    Nat Struct Mol Biol 17, 1241 - 1246 (2010)

    [doi: http://dx.doi.org/10.1038/nsmb.1896]

  • Structural basis of HIV-1 resistance to AZT by excision

    Tu X., Das K., Han Q., Bauman J., D A. et al.

    Nat Struct Mol Biol 17, 1202 - 1209 (2010)

    [doi: http://dx.doi.org/10.1038/nsmb.1908]

  • The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site

    Li Q., Qi J., Zhang W., Vavricka C., Shi Y. et al.

    Nat Struct Mol Biol 17, 1266 - 1268 (2010)

    [doi: http://dx.doi.org/10.1038/nsmb.1909]

  • Structural basis of substrate recognition and specificity in the N-end rule pathway

    Matta-Camacho E., Kozlov G., Li F. and Gehring K.

    Nat Struct Mol Biol 17, 1182 - 1187 (2010)

    [doi: http://dx.doi.org/10.1038/nsmb.1894]

  • Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases

    Choi W., Jeong B., Joo Y., Lee M., Kim J. et al.

    Nat Struct Mol Biol 17, 1175 - 1181 (2010)

    [doi: http://dx.doi.org/10.1038/nsmb.1907]

  • Cooperative interaction of transcription termination factors with the RNA polymerase II C-terminal domain

    Lunde B., Reichow S., Kim M., Suh H., Leeper T. et al.

    Nat Struct Mol Biol 17, 1195 - 1201 (2010)

    [doi: http://dx.doi.org/10.1038/nsmb.1893]

  • A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses

    Sun D., Lee G., Lee J., Kim H., Rhee H. et al.

    Nat Struct Mol Biol 17, 1188 - 1194 (2010)

    [doi: http://dx.doi.org/10.1038/nsmb.1906]

  • Neurological disease mutations compromise a C-terminal ion pathway in the Na+/K+-ATPase

    Poulsen H., Khandelia H., Morth J., Bublitz M., Mouritsen O. et al.

    Nature 467, 99 - 102 (2010)

    [doi: http://dx.doi.org/10.1038/nature09309]

  • Molecular basis of FIR-mediated c-myc transcriptional control

    Cukier C., Hollingworth D., Martin S., Kelly G., Diaz-Moreno I. et al.

    Nat Struct Mol Biol 17, 1058 - 1064 (2010)

    [doi: http://dx.doi.org/10.1038/nsmb.1883]

  • Structure of the LexA-DNA complex and implications for SOS box measurement

    Zhang A., Pigli Y. and Rice P.

    Nature 466, 883 - 886 (2010)

    [doi: http://dx.doi.org/10.1038/nature09200]

  • An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein

    Hirschi A., Cecchini M., Steinhardt R., Schamber M., Dick F. et al.

    Nat Struct Mol Biol 17, 1051 - 1057 (2010)

    [doi: http://dx.doi.org/10.1038/nsmb.1868]

  • Substrate and drug binding sites in LeuT

    Nyola A., Karpowich N.K., Zhen J., Marden J., Reith M.E.

    Curr Opin Struct Biol 20, 415 - 422 (2010)

    [doi: http://dx.doi.org/10.1016/j.sbi.2010.05.007]

  • SARS coronavirus unique domain: three-domain molecular architecture in solution and RNA binding

    Johnson M., Chatterjee A., Neuman B. and Wüthrich K.

    J Mol Biol 400, 724 - 742 (2010)

    [doi: http://dx.doi.org/10.1016/j.jmb.2010.05.027]

  • A comprehensive analysis of structural and sequence conservation in the TetR family transcriptional regulators

    Yu Z., Reichheld S.E., Savchenko A., Parkinson J., Davidson A.R.

    J Mol Biol 400, 847 - 864 (2010)

    [doi: http://dx.doi.org/10.1016/j.jmb.2010.05.062]

  • Functional Modules and Structural Basis of Conformational Coupling in Mitochondrial Complex I

    Hunte C., Zickermann V. and Brandt U.

    Science 329, 448 - 451 (2010)

    [doi: http://dx.doi.org/10.1126/science.1191046]

  • Dead-end filling of SlipChip evaluated theoretically and experimentally as a function of the surface chemistry and the gap size between the plates for lubricated and dry SlipChips

    Li L., Karymov M.A., Nichols K.P., Ismagilov R.F.

    Langmuir. 26, 12465 - 12471 (2010)

    [doi: http://dx.doi.org/10.1021/la101460z]

  • TM0486 from the hyperthermophilic anaerobe Thermotoga maritima is a thiamin-binding protein involved in response of the cell to oxidative conditions

    Dermoun Z., Foulon A., Miller M., Harrington D., Deacon A. et al.

    J Mol Biol 400, 463 - 476 (2010)

    [doi: http://dx.doi.org/10.1016/j.jmb.2010.05.014]

  • Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne

    Bremm A., Freund S. and Komander D.

    Nat Struct Mol Biol 17, 939 - 947 (2010)

    [doi: http://dx.doi.org/10.1038/nsmb.1873]

  • Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain

    Hom R.A., Chang P.Y., Roy S., Musselman C.A., Glass K.C.

    J Mol Biol 400, 145 - 154 (2010)

    [doi: http://dx.doi.org/10.1016/j.jmb.2010.04.067]

  • Structure and activity of the metal-independent fructose-1,6-bisphosphatase YK23 from Saccharomyces cerevisiae

    Kuznetsova E., Xu L., Singer A., Brown G., Dong A. et al.

    J Biol Chem 285, 21049 - 21059 (2010)

    [doi: http://dx.doi.org/10.1074/jbc.M110.118315]

  • Structure of the gating ring from the human large-conductance Ca2+-gated K+ channel

    Wu Y., Yang Y., Ye S. and Jiang Y.

    Nature 466, 393 - 397 (2010)

    [doi: http://dx.doi.org/10.1038/nature09252]

  • Discovery and structure determination of the orphan enzyme isoxanthopterin deaminase

    Hall R., Agarwal R., Hitchcock D., Sauder J., Burley S. et al.

    Biochemistry 49, 4374 - 4382 (2010)

    [doi: http://dx.doi.org/10.1021/bi100252s]

  • Heme proteins--diversity in structural characteristics, function, and folding

    Smith L.J., Kahraman A., Thornton J.M.

    Proteins 78, 2349 - 2368 (2010)

    [doi: http://dx.doi.org/10.1002/prot.22747]

  • Solution NMR structure of Lin0431 protein from Listeria innocua reveals high structural similarity with domain II of bacterial transcription antitermination protein NusG

    Tang Y., Xiao R., Ciccosanti C., Janjua H., Lee D. et al.

    Proteins 78, 2563 - 2568 (2010)

    [doi: http://dx.doi.org/10.1002/prot.22760]

  • Structural basis of O6-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein

    Aramini J., Tubbs J., Kanugula S., Rossi P., Ertekin A. et al.

    J Biol Chem 285, 13736 - 13741 (2010)

    [doi: http://dx.doi.org/10.1074/jbc.M109.093591]

  • Structure of a virulence regulatory factor CvfB reveals a novel winged helix RNA binding module.

    Matsumoto Y., Xu Q., Miyazaki S., Kaito C., Farr C. et al.

    Structure 18, 537 - 547 (2010)

    [doi: http://dx.doi.org/10.1016/j.str.2010.02.007]

  • The structure of DinB from Geobacillus stearothermophilus: a representative of a unique four-helix-bundle superfamily

    Cooper D.R., Grelewska K., Kim C.Y., Joachimiak A., Derewenda Z.S.

    Acta Crystallogr Sect F Struct Biol Cryst Commun 66, 219 - 224 (2010)

    [doi: http://dx.doi.org/10.1107/S1744309109053913]

  • Crystal structure and molecular modeling study of N-carbamoylsarcosine amidase Ta0454 from Thermoplasma acidophilum

    Luo H.B., Zheng H., Zimmerman M.D., Chruszcz M., Skarina T.

    J Struct Biol 169, 304 - 311 (2010)

    [doi: http://dx.doi.org/10.1016/j.jsb.2009.11.008]

  • Structure of bovine pancreatic ribonuclease complexed with uridine 5'-monophosphate at 1.60 A resolution

    Larson S.B., Day J.S., Nguyen C., Cudney R., McPherson A.

    Acta Crystallogr Sect F Struct Biol Cryst Commun 66, 113 - 120 (2010)

    [doi: http://dx.doi.org/10.1107/S174430910905194X]

  • TOPSAN: a collaborative annotation environment for structural genomics

    Weekes D., Krishna S.S., Bakolitsa C., Wilson I.A., Godzik A.

    BMC Bioinformatics. 11, 426 (2010)

    [doi: http://dx.doi.org/10.1186/1471-2105-11-426]

  • Crystal structure of an eIF4G-like protein from Danio rerio

    Bae E., Bitto E., Bingman C., McCoy J., Wesenberg G. et al.

    Proteins 78, 1803 - 1806 (2010)

    [doi: http://dx.doi.org/10.1002/prot.22703]

  • Structures of the autoproteolytic domain from the Saccharomyces cerevisiae nuclear pore complex component, Nup145

    Sampathkumar P., Ozyurt S., Do J., Bain K., Dickey M. et al.

    Proteins 78, 1992 - 1998 (2010)

    [doi: http://dx.doi.org/10.1002/prot.22707]

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