research advances

• The Immune System: Strand Swapping for T-Cell Inhibition

  An immunoglobulin protein with a role in antigen-independent T-cell signaling dimerizes via a strand-swapped interface.

• The Immune System: A Strong Competitor

  HLA-DO is an MHCII mimic that prevents the association of HLA-DM to MHCII.

• The Immune System: A Brotherhood of Immunoglobulins

  The Brotherhood algorithm groups proteins into functional families using indirect sequence similarity.

• The Immune System: Super Cytokines

  Crystal structures of cytokine receptor complexes pinpoint target regions to create 'superkines' with altered cell specificity.

• more this month

• featured system

  • Tuning Immune Response with Costimulation

    PSI researchers are studying molecules that stimulate and inhibit our immune response, ensuring that it is activated only when necessary.

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• news

  • PSI in the spotlight
  • Protein gets in on DNA's origami act
  • Molecules in the brain trigger ageing

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• research library

  • The structure and enzymatic properties of a novel RNase II family enzyme from Deinococcus radiodurans.
  • Improved expression and purification of sigma 1 receptor fused to maltose binding protein by alteration of linker sequence.

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• events

  • 2013 Annual Meeting of the American Crystallographic Association July 20, 2013 - July 24, 2013
    Honolulu, Hawaii, USA
  • 7th International Conference on Structural Genomics (ICSG 2013) July 29, 2013 - August 1, 2013
    Sapporo, Japan

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