Synopses of important developments in the field of structural biology and structural genomics, including advances from the Protein Structure Initiative. The featured articles and technical highlights are specially written for the Structural Biology Knowledgebase, while the research highlights are taken from NPG publications.
Biochemical, structural and genetic analyses reveal that the E. coli Cas1 protein YgbT belongs to a novel family of nucleases and that, in addition to antiviral immunity, the CRISPR–Cas system functions in DNA repair.
While the NDRG family has been implicated in a number of diseases and cancers, the molecular function of these factors remains unclear. The structures of NDRG2 reveal unusual features that give insight into these functions.