research advances
Synopses of important developments in the field of structural biology and structural genomics, including advances from the Protein Structure Initiative. The featured articles and technical highlights are specially written for the Structural Biology Knowledgebase, while the research highlights are taken from NPG publications.
February 2010
featured articles
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Extremely salty
Salt-loving archaea use small negative amino acids to survive hostile conditions.
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Urea transporter
The X-ray crystal structure of a bacterial homolog of the mammalian urea transporter reveals a highly specific, channel-like transport mechanism.
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research highlights
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Signalling: ABA's greatest hitsAlthough many components of the ABA signalling pathway are known, the identity and signalling mechanisms of ABA receptors have remained elusive.
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The importance of being negativeThe Negatome is a database of non-interacting protein pairs that can be used for training protein-protein interaction prediction algorithms.
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technical highlights
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Deducing function from small structural cluesFind structural similarities without relying on fold classification by using the MarkUs server.
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Tips for crystallizing membrane proteins in lipidic mesophasesAdvice on this useful technique for crystallizing integral membrane proteins.
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