Metrics Describing Progress of the Protein Structure Initiative

Updated December 01, 2011

I. Progress of the PSI
• PDB deposition statistics
• Numbers of experimental structures from PSI
II. Number of Experimental Structures and Residues
• Structures determined in PSI-1
• Structures determined in PSI-2
III. Impact and Classification of Structures
• Classification of PSI-2 structures
• Classification of PSI-2 structures by organism
• Detailed PSI-2 structure counts for eukaryotes
• Detailed PSI-2 structure counts for prokaryotes
• Detailed PSI-2 structure counts for other organisms
IV. Novel Modeling Leverage
• Leverage provided by PSI-2 structures
V. Biological Theme Targets & Structures
• Biological Theme Targets & Structures by PSI Center
• Biomedical Targets & Structures by PSI Center
• Metagenomic Targets & Structures by PSI Center
• Community Nominated Targets & Structures by PSI Center
VI. PSI PFAM Domain Family Covarage
• PFAM Domain Family Covarage

Glossary of Terms

• BIG: BioInformatics Group. A team of bioinformaticians from PSI-2 large-scale production centers that coordinate efforts of target selection and progress evaluation
• ALL-PSI: All PSI centers (PSI-1, PSI-2, PSI-3)
• ALL PDB: Entire Protein Data Bank
• PSI-1: The pilot phase of the protein structure initiative (PSI) ran from 09-01-2000 to 06-30-2005
• PSI-2: The production phase of the protein structure initiative (PSI) (07-01-2005 - ongoing). Statistics on this page reflect PSI-2 data deposited after 07-01-2005 and released before 12-01-2011
• PSI-3: The PSI:Biology program of the protein structure initiative (PSI) (07-01-2010 - ongoing). Statistics on this page reflect PSI-3 data deposited after 07-01-2010 and released before 12-01-2011
• LSC: are the four Protein Structure Initiative (PSI) large-scale production centers; namely MCSG, JCSG, NESG, and NYSGXRC/NYSGRC
• Total Structures: Total number of structures in the PDB at the time of deposition. This includes multiple structures of the same protein sequence determined by different methods (i.e., NMR versus X-ray crystallography), in different crystal forms, different solution conditions, or bound to different ligands.
• Distinct Structures: Total number of structures with non-redundant sequences less then 98% sequence identity
• Distinct Residues: Total number of residues in structures with non-redundant sequences less 98% sequence identity
• Novel Structures: Total number of novel structures with less than 30% sequence identity to an existing structure at the time of PDB deposition
• Novel Residues: Total number of residues in structures with less than 30% sequence identity to an existing structure at the time of PDB deposition
• X-Ray Structures: Total number of structures determined using X-Ray crystallography
• NMR Structures: Total number of structures determined using NMR methods
• Membrane Proteins: Total number of structures of membrane proteins
• Eukaryotic Proteins: Total number of structures from eukaryotic organisms
• Prokaryotic Proteins: Total number of structures from prokaryotic organisms
• Human Proteins: Total number of structures of human proteins
• Other Proteins: Total number of structures of viral and unknown source proteins

I. Progress of the PSI

PDB deposition statistics

PSI grant period	LSC	ALL-PSI
PSI-2 grant year 2005	390	427
PSI-2 grant year 2006	620	700
PSI-2 grant year 2007	682	718
PSI-2 grant year 2008	796	818
PSI-2 grant year 2009	822	879
PSI-2 grant extension	217	244
PSI-2 total depositions	3527	3786
PSI-3 grant year 2010	280	283
PSI-3 total depositions	377	381
PSI-1 + PSI-2 + PSI-3	4804	5583

PSI-2 grant year 2005:
PSI-2 structures deposited between July 1, 2005 and July 1, 2006
PSI-2 grant year 2006:
PSI-2 structures deposited between July 1, 2006 and July 1, 2007
PSI-2 grant year 2007:
PSI-2 structures deposited between July 1, 2007 and July 1, 2008
PSI-2 grant year 2008:
PSI-2 structures deposited between July 1, 2008 and July 1, 2009
PSI-2 grant year 2009:
PSI-2 structures deposited between July 1, 2009 and July 1, 2010
PSI-2 grant extension:
PSI-2 structures deposited between July 1, 2010 and December 01, 2011
PSI-2 total depositions:
PSI-2 structures deposited between July 1, 2005 and December 01, 2011
PSI-3 grant year 2010:
PSI-3 structures deposited between July 1, 2010 and July 1, 2011
PSI-3 total depositions:
PSI-3 structures deposited between July 1, 2010 and December 01, 2011
PSI-1 + PSI-2 + PSI-3:
All PSI structures released before December 01, 2011

Numbers of experimental structures from PSI

Start of PSI Deposition:
Sep 2000: Structures deposited before PSI grant initiation (2000-09-01)

Each subsequent bar shows the total number of PSI structures deposited as of the First of each indicated date.

For example, there were 96 PSI-derived structures deposited as of September 1, 2001.

II. Number of Experimental Structures and Residues

Structures determined in PSI-1

Center	Total Structures	Distinct Structures	Distinct Residues	Novel Structures	Novel Residues
LSC	898	792	180109	453	99731
ALL-PSI-1	1416	1157	265929	622	137025
ALL PDB	19865	7111	1704005	2735	645949

Calculations in this table are based on PDB data deposited before July 1, 2005

Structures determined in PSI-2

Center	Total Structures	Distinct Structures	Distinct Residues	Novel Structures	Novel Residues
LSC	3527	3166	719603	1957	441959
ALL-PSI-2	3786	3271	744587	2018	456021
ALL PDB	43100	15604	3975602	5922	1435827

Calculations in this table are based on PDB data deposited after July 1, 2005 and released before December 01, 2011.

III. Impact and Classification of PSI-2 Structures

Calculations in this section are based on PDB data deposited after July 1, 2005 and released before December 01, 2011.

Classification of PSI-2 structures

Center	Total Structures	X-ray	NMR	Membrane Proteins	Eukary- otes	Human	Other	Prokary- otes
LSC	3527	3159	368	24	185	100	46	3274
ALL-PSI-2	3786	3380	406	81	345	147	58	3360

Classification of PSI-2 structures by organism

Eukaryotes Total	345
Prokaryotes Total	3360
Other Organisms Total	58

Detailed PSI-2 structure counts for eukaryotes

Eukaryotes Total	345
Aequorea victoria	1
Anopheles gambiae	2
Antirrhinum majus	1
Arabidopsis thaliana	59
Ashbya gossypii	2
Aspergillus fumigatus	1
Aspergillus oryzae	2
Babesia bovis	1
Bos taurus	3
Brugia malayi	1
Caenorhabditis elegans	11
Candida albicans	1
Candida glabrata	1
Coccidioides immitis	1
Cyanidioschyzon merolae	1
Danio rerio	7
Drosophila melanogaster	3
Encephalitozoon cuniculi	4
Engyodontium album	1
Galdieria sulphuraria	7
Gibberella zeae	2
Homo sapiens	147
Mus musculus	35
Oncorhynchus mykiss	1
Oryza sativa	1
Pentadiplandra brazzeana	1
Pichia guilliermondii	1
Rana pipiens	2
Rattus norvegicus	5
Saccharomyces cerevisiae	30
Schizosaccharomyces pombe	2
Solanum lycopersicum	1
Spinacia oleracea	1
Sus scrofa	1
Toxoplasma gondii	3
Trypanosoma brucei	1
Xenopus laevis	1

Detailed PSI-2 structure counts for prokaryotes

Prokaryotes Total

3360

Genus: Acidithiobacillus 5 Acidithiobacillus ferrooxidans 5 Genus: Acidothermus 1 Acidothermus cellulolyticus 1 Genus: Acinetobacter 9 Acinetobacter baumannii 1 Acinetobacter calcoaceticus 1 Acinetobacter sp. 7 Genus: Actinobacillus 3 Actinobacillus succinogenes 3 Genus: Aeromonas 4 Aeromonas hydrophila 1 Aeromonas salmonicida 3 Genus: Aeropyrum 5 Aeropyrum pernix 5 Genus: Agrobacterium 96 Agrobacterium tumefaciens 95 Agrobacterium vitis 1 Genus: Alcanivorax 2 Alcanivorax borkumensis 2 Genus: Alicyclobacillus 1 Alicyclobacillus acidocaldarius 1 Genus: Alkaliphilus 2 Alkaliphilus metalliredigens 2 Genus: Allochromatium 1 Allochromatium vinosum 1 Genus: Alteromonas 1 Alteromonas macleodii 1 Genus: Anabaena 23 Anabaena sp. 1 Anabaena variabilis 22 Genus: Aquifex 9 Aquifex aeolicus 9 Genus: Archaeoglobus 59 Archaeoglobus fulgidus 59 Genus: Arthrobacter 11 Arthrobacter aurescens 5 Arthrobacter sp. 6 Genus: Azoarcus 1 Azoarcus sp. 1 Genus: Azorhizobium 1 Azorhizobium caulinodans 1 Genus: Azotobacter 2 Azotobacter vinelandii 2 Genus: Bacillus 266 Bacillus anthracis 15 Bacillus cereus 53 Bacillus clausii 2 Bacillus cytotoxicus 1 Bacillus halodurans 55 Bacillus licheniformis 2 Bacillus subtilis 127 Bacillus thuringiensis 11 Genus: Bacteroides 205 Bacteroides caccae 1 Bacteroides fragilis 56 Bacteroides ovatus 9 Bacteroides thetaiotaomicron 107 Bacteroides uniformis 1 Bacteroides vulgatus 31 Genus: Bartonella 7 Bartonella henselae 7 Genus: Bdellovibrio 2 Bdellovibrio bacteriovorus 2 Genus: Bermanella 1 Bermanella marisrubri 1 Genus: Bifidobacterium 12 Bifidobacterium adolescentis 7 Bifidobacterium longum 5 Genus: Blastochloris 1 Blastochloris viridis 1 Genus: Bordetella 47 Bordetella bronchiseptica 20 Bordetella parapertussis 16 Bordetella pertussis 11 Genus: Borrelia 1 Borrelia burgdorferi 1 Genus: Bradyrhizobium 3 Bradyrhizobium japonicum 3 Genus: Burkholderia 37 Burkholderia mallei 4 Burkholderia phymatum 1 Burkholderia phytofirmans 2 Burkholderia pseudomallei 4 Burkholderia sp. 1 Burkholderia thailandensis 7 Burkholderia xenovorans 18 Genus: Caldicellulosiruptor 1 Caldicellulosiruptor saccharolyticus 1 Genus: Campylobacter 11 Campylobacter jejuni 11 Genus: Carboxydothermus 2 Carboxydothermus hydrogenoformans 2 Genus: Caulobacter 13 Caulobacter crescentus 7 Caulobacter vibrioides 6 Genus: Chlamydia 1 Chlamydia trachomatis 1 Genus: Chlamydophila 1 Chlamydophila abortus 1 Genus: Chlorobaculum 13 Chlorobaculum tepidum 13 Genus: Chlorobium 10 Chlorobium tepidum 10 Genus: Chloroflexus 5 Chloroflexus aggregans 1 Chloroflexus aurantiacus 4 Genus: Chromobacterium 23 Chromobacterium violaceum 23 Genus: Chromohalobacter 4 Chromohalobacter salexigens 4 Genus: Clostridium 84 Clostridium acetobutylicum 31 Clostridium beijerinckii 1 Clostridium difficile 19 Clostridium leptum 3 Clostridium novyi 3 Clostridium perfringens 12 Clostridium phytofermentans 3 Clostridium symbiosum 3 Clostridium tetani 1 Clostridium thermocellum 8 Genus: Colwellia 10 Colwellia psychrerythraea 10 Genus: Corynebacterium 64 Corynebacterium diphtheriae 24 Corynebacterium glutamicum 40 Genus: Coxiella 1 Coxiella burnetii 1 Genus: Cupriavidus 2 Cupriavidus metallidurans 1 Cupriavidus necator 1 Genus: Cytophaga 25 Cytophaga hutchinsonii 25 Genus: Deinococcus 22 Deinococcus geothermalis 3 Deinococcus radiodurans 19 Genus: Desulfitobacterium 20 Desulfitobacterium hafniense 20 Genus: Desulfotalea 2 Desulfotalea psychrophila 2 Genus: Desulfovibrio 21 Desulfovibrio desulfuricans 9 Desulfovibrio vulgaris 12 Genus: Desulfuromonas 1 Desulfuromonas acetoxidans 1 Genus: Dyadobacter 1 Dyadobacter fermentans 1 Genus: Enterococcus 65 Enterococcus faecalis 62 Enterococcus faecium 3 Genus: Erwinia 2 Erwinia carotovora 2 Genus: Escherichia 120 Escherichia coli 120 Genus: Eubacterium 13 Eubacterium eligens 3 Eubacterium rectale 6 Eubacterium ventriosum 4 Genus: Exiguobacterium 17 Exiguobacterium sibiricum 17 Genus: Fervidobacterium 1 Fervidobacterium nodosum 1 Genus: Frankia 1 Frankia sp. 1 Genus: Fulvimarina 1 Fulvimarina pelagi 1 Genus: Fusobacterium 4 Fusobacterium nucleatum 4 Genus: Geobacillus 17 Geobacillus kaustophilus 2 Geobacillus sp. 3 Geobacillus stearothermophilus 10 Geobacillus thermodenitrificans 2 Genus: Geobacter 28 Geobacter metallireducens 11 Geobacter sulfurreducens 17 Genus: Gloeobacter 1 Gloeobacter violaceus 1 Genus: Haemophilus 39 Haemophilus ducreyi 3 Haemophilus influenzae 28 Haemophilus somnus 8 Genus: Hahella 2 Hahella chejuensis 2 Genus: Haloarcula 7 Haloarcula marismortui 7 Genus: Halobacterium 1 Halobacterium sp. 1 Genus: Halorhodospira 1 Halorhodospira halophila 1 Genus: Helicobacter 20 Helicobacter pylori 20 Genus: Herpetosiphon 1 Herpetosiphon aurantiacus 1 Genus: Idiomarina 3 Idiomarina baltica 1 Idiomarina loihiensis 2 Genus: Jannaschia 14 Jannaschia 1 Jannaschia sp. 13 Genus: Jonesia 1 Jonesia denitrificans 1 Genus: Klebsiella 27 Klebsiella pneumoniae 26 Klebsiella variicola 1 Genus: Kosmotoga 1 Kosmotoga olearia 1 Genus: Lactobacillus 70 Lactobacillus acidophilus 11 Lactobacillus brevis 10 Lactobacillus casei 5 Lactobacillus delbrueckii 4 Lactobacillus plantarum 36 Lactobacillus reuteri 1 Lactobacillus salivarius 3 Genus: Lactococcus 6 Lactococcus lactis 6 Genus: Leeuwenhoekiella 1 Leeuwenhoekiella blandensis 1 Genus: Legionella 25 Legionella pneumophila 25 Genus: Leptospirillum 5 Leptospirillum rubarum 5 Genus: Listeria 71 Listeria innocua 36 Listeria monocytogenes 35 Genus: Magnetospirillum 5 Magnetospirillum magneticum 1 Magnetospirillum magnetotacticum 4 Genus: Mannheimia 1 Mannheimia succiniciproducens 1 Genus: Marine 2 Marine actinobacterium 2 Genus: Marinobacter 8 Marinobacter aquaeolei 8

Genus: Mesorhizobium 20 Mesorhizobium loti 18 Mesorhizobium sp. 2 Genus: Methanocaldococcus 28 Methanocaldococcus jannaschii 28 Genus: Methanococcus 12 Methanococcus jannaschii 2 Methanococcus maripaludis 10 Genus: Methanocorpusculum 1 Methanocorpusculum labreanum 1 Genus: Methanoculleus 2 Methanoculleus marisnigri 2 Genus: Methanopyrus 3 Methanopyrus kandleri 3 Genus: Methanosarcina 22 Methanosarcina acetivorans 2 Methanosarcina mazei 20 Genus: Methanospirillum 2 Methanospirillum hungatei 2 Genus: Methanothermobacter 18 Methanothermobacter marburgensis 2 Methanothermobacter thermautotrophicus 16 Genus: Methylibium 2 Methylibium petroleiphilum 2 Genus: Methylobacillus 12 Methylobacillus flagellatus 12 Genus: Methylococcus 5 Methylococcus capsulatus 5 Genus: Micromonospora 7 Micromonospora echinospora 7 Genus: Moorella 1 Moorella thermoacetica 1 Genus: Mycobacterium 22 Mycobacterium bovis 4 Mycobacterium smegmatis 3 Mycobacterium tuberculosis 14 Mycobacterium vanbaalenii 1 Genus: Mycoplasma 2 Mycoplasma synoviae 2 Genus: Myxococcus 2 Myxococcus xanthus 2 Genus: Neisseria 36 Neisseria gonorrhoeae 9 Neisseria meningitidis 27 Genus: Neptuniibacter 1 Neptuniibacter caesariensis 1 Genus: Nitrosomonas 28 Nitrosomonas europaea 28 Genus: Nitrosospira 5 Nitrosospira multiformis 5 Genus: Nocardia 1 Nocardia farcinica 1 Genus: Nostoc 36 Nostoc punctiforme 20 Nostoc sp. 16 Genus: Novosphingobium 23 Novosphingobium aromaticivorans 23 Genus: Oceanicola 1 Oceanicola granulosus 1 Genus: Oceanobacillus 6 Oceanobacillus iheyensis 6 Genus: Oenococcus 7 Oenococcus oeni 7 Genus: Oleispira 8 Oleispira antarctica 8 Genus: Parabacteroides 23 Parabacteroides distasonis 23 Genus: Paracoccus 2 Paracoccus denitrificans 2 Genus: Pectobacterium 18 Pectobacterium atrosepticum 17 Pectobacterium carotovorum 1 Genus: Pediococcus 5 Pediococcus pentosaceus 5 Genus: Pelobacter 1 Pelobacter carbinolicus 1 Genus: Picrophilus 1 Picrophilus torridus 1 Genus: Polaromonas 4 Polaromonas sp. 4 Genus: Porphyromonas 38 Porphyromonas gingivalis 38 Genus: Prevotella 1 Prevotella bryantii 1 Genus: Prochlorococcus 6 Prochlorococcus marinus 6 Genus: Proteus 1 Proteus mirabilis 1 Genus: Pseudoalteromonas 2 Pseudoalteromonas atlantica 2 Genus: Pseudomonas 163 Pseudomonas aeruginosa 86 Pseudomonas fluorescens 20 Pseudomonas mendocina 1 Pseudomonas putida 18 Pseudomonas sp. 1 Pseudomonas syringae 37 Genus: Pseudovibrio 2 Pseudovibrio sp. 2 Genus: Psychrobacter 6 Psychrobacter arcticus 6 Genus: Pyrococcus 30 Pyrococcus furiosus 15 Pyrococcus horikoshii 15 Genus: Ralstonia 32 Ralstonia eutropha 26 Ralstonia pickettii 1 Ralstonia solanacearum 5 Genus: Rhizobium 4 Rhizobium etli 2 Rhizobium leguminosarum 2 Genus: Rhodobacter 24 Rhodobacter capsulatus 3 Rhodobacter sphaeroides 21 Genus: Rhodococcus 34 Rhodococcus 1 Rhodococcus jostii 5 Rhodococcus sp. 28 Genus: Rhodopirellula 2 Rhodopirellula baltica 2 Genus: Rhodopseudomonas 45 Rhodopseudomonas palustris 45 Genus: Rhodospirillum 14 Rhodospirillum rubrum 14 Genus: Roseovarius 7 Roseovarius nubinhibens 6 Roseovarius sp. 1 Genus: Rubrobacter 2 Rubrobacter xylanophilus 2 Genus: Ruegeria 14 Ruegeria pomeroyi 11 Ruegeria sp. 3 Genus: Ruminococcus 12 Ruminococcus gnavus 3 Ruminococcus obeum 9 Genus: Salinibacter 4 Salinibacter ruber 4 Genus: Salmonella 45 Salmonella enterica 10 Salmonella paratyphi 1 Salmonella typhimurium 34 Genus: Shewanella 94 Shewanella amazonensis 10 Shewanella baltica 8 Shewanella denitrificans 7 Shewanella frigidimarina 8 Shewanella loihica 9 Shewanella oneidensis 46 Shewanella pealeana 1 Shewanella putrefaciens 4 Shewanella sp. 1 Genus: Shigella 31 Shigella flexneri 31 Genus: Silicibacter 41 Silicibacter pomeroyi 33 Silicibacter sp. 8 Genus: Sinorhizobium 11 Sinorhizobium medicae 1 Sinorhizobium meliloti 10 Genus: Sphingomonas 1 Sphingomonas paucimobilis 1 Genus: Spirosoma 1 Spirosoma linguale 1 Genus: Staphylococcus 64 Staphylococcus aureus 37 Staphylococcus epidermidis 14 Staphylococcus haemolyticus 4 Staphylococcus saprophyticus 9 Genus: Streptococcus 110 Streptococcus agalactiae 15 Streptococcus mutans 19 Streptococcus pneumoniae 47 Streptococcus pyogenes 16 Streptococcus suis 3 Streptococcus thermophilus 10 Genus: Streptomyces 57 Streptomyces avermitilis 19 Streptomyces coelicolor 38 Genus: Sulfolobus 27 Sulfolobus solfataricus 27 Genus: Sulfurospirillum 1 Sulfurospirillum deleyianum 1 Genus: Synechococcus 9 Synechococcus elongatus 7 Synechococcus sp. 2 Genus: Synechocystis 13 Synechocystis 1 Synechocystis sp. 12 Genus: Syntrophomonas 3 Syntrophomonas wolfei 3 Genus: Syntrophus 4 Syntrophus aciditrophicus 4 Genus: Thermobifida 10 Thermobifida fusca 10 Genus: Thermococcus 1 Thermococcus kodakarensis 1 Genus: Thermoplasma 38 Thermoplasma acidophilum 30 Thermoplasma volcanium 8 Genus: Thermosynechococcus 2 Thermosynechococcus elongatus 2 Genus: Thermotoga 90 Thermotoga maritima 89 Thermotoga sp. 1 Genus: Thermus 4 Thermus thermophilus 4 Genus: Thiobacillus 4 Thiobacillus denitrificans 4 Genus: Treponema 1 Treponema denticola 1 Genus: Uncultured 6 Uncultured bacterium 5 Uncultured thermotogales 1 Genus: Ureaplasma 3 Ureaplasma parvum 3 Genus: Vibrio 101 Vibrio cholerae 38 Vibrio fischeri 10 Vibrio paracholerae 1 Vibrio parahaemolyticus 51 Vibrio splendidus 1 Genus: Vibrionales 1 Vibrionales bacterium 1 Genus: Wolinella 7 Wolinella succinogenes 7 Genus: Xanthomonas 18 Xanthomonas campestris 18 Genus: Xylella 7 Xylella fastidiosa 7 Genus: Yersinia 8 Yersinia enterocolitica 2 Yersinia pestis 1 Yersinia pseudotuberculosis 5 Genus: Zymomonas 1 Zymomonas mobilis 1

Detailed PSI-2 structure counts for other organisms

Other Organisms Total	58
Chimera	1
Rattus norvegicus, saccharomyces cerevisiae	1
Unknown	21
Artificial gene	4
Uncultured marine organism	6
Unidentified	11
Virus	36
Bacteriophage p1	1
Homo sapiens, bacteriophage t4	1
Homo sapiens, enterobacteria phage t4	9
Homo sapiens, enterobacteria phage t4, homo sapiens	1
Influenza a virus	2
Mengo virus	1
Moloney murine leukemia virus	1
Murid herpesvirus 4	2
Pseudomonas phage luz7	1
Pseudomonas phage phi12	1
Pseudomonas phage yua	1
Sars coronavirus	13
Staphylococcus phage	1
Vaccinia virus wr	1

IV. Novel Modeling Leverage

Calculations in this section updated October 5, 2011

Modeling leverage caculations are provided by Dr.Lukasz Jaroszewski affiliated with JCSG

Leverage provided by PSI-2 structures

Center	Total Leverage	Residue Leverage	Novel Leverage	Residue Leverage
LSC	1233729	304119628	250016	64765245
PSI-2	1462817	352173350	266758	69997509
PDB excluding PSI-2	3828929	1115315109	635537	241783799

V. Biological Theme Targets & Structures

Calculations in this section updated December 01, 2011

Biological Theme Targets by PSI Center

Center	Biomedical Targets	Metagenomics Targets	Community Nominated Targets
ATCG3D	7	0	0
CESG	983	0	442
CHTSB	129	0	0
GPCR	0	0	3
ISFI	0	0	428
JCSG	21843	2436	2078
MCSG	4318	1500	1945
MPP	232	0	284
NESG	8561	1847	811
NYCOMPS	0	0	532
NYSGRC	9593	0	302
NYSGXRC	1335	485	1489
TMPC	48	0	49
Total	54744	6268	11410

Biomedical Targets & Structures by PSI Center

Center	Total Targets	Cloned Targets	Expressed Targets	Purified Targets	Crystallyzed Targets	NMR Targets	Targets In PDB	Structures In PDB
ATCG3D	7	7	7	7	6	0	6	8
CESG	983	770	689	173	32	3	10	8
CHTSB	129	124	29	10	0	0	5	21
JCSG	21843	21108	12469	12467	1857	0	738	798
MCSG	4318	3515	2595	1265	287	0	276	304
MPP	232	51	47	5	0	0	0	0
NESG	8561	2578	2418	736	50	89	129	141
NYSGRC	9593	2089	1794	481	51	0	41	43
NYSGXRC	1335	1010	911	462	107	0	69	77
TMPC	48	32	26	10	0	0	0	0
Total	54744	35893	24306	16833	2390	92	1274	1711

Metagenomic Targets & Structures by PSI Center

Center	Total Targets	Cloned Targets	Expressed Targets	Purified Targets	Crystallyzed Targets	NMR Targets	Targets In PDB	Structures In PDB
JCSG	2436	2348	1625	1625	387	0	113	116
MCSG	1500	1430	860	323	70	0	64	71
NESG	1847	1127	1123	409	45	28	67	77
NYSGXRC	485	451	396	207	52	0	31	35
Total	6268	5356	4004	2564	554	28	275	299

Community Nominated Targets & Structures by PSI Center

Center	Total Targets	Cloned Targets	Expressed Targets	Purified Targets	Crystallyzed Targets	NMR Targets	Targets In PDB	Structures In PDB
CESG	442	313	243	81	39	12	30	40
GPCR	3	3	0	0	0	0	0	0
ISFI	428	330	244	210	175	0	129	13
JCSG	2078	1992	1573	1573	363	0	111	113
MCSG	1945	1614	1304	581	128	0	49	50
MPP	284	180	165	28	0	0	0	0
NESG	811	564	523	292	49	38	83	97
NYCOMPS	532	362	90	43	0	0	0	0
NYSGRC	302	302	297	56	17	0	11	14
NYSGXRC	1489	1288	1066	514	174	0	128	178
TMPC	49	41	27	8	0	0	0	0
Total	11410	8555	6572	3808	945	50	541	589

VI. PSI PFAM Domain Family Coverage

Calculations in this section updated October 5, 2011

Number of PFAM families for which PSI provided the first structure representative

Total PFAM Families	Total PFAM Families in PDB	PSI-1 PFAM Families	PSI-2 PFAM Families
12273	5564	355	561