Website:

http://www.proteinmodelportal.org

Description:

The Protein Model Portal gives access to the various models that can be leveraged from PSI targets and other experimental protein structures by comparative modelling methods. The current release of the portal allows searching 8.1 million precomputed model structures provided by different partner sites, and provides access to various interactive services for template selection, target-template alignment, model building, and quality assessment.

The Protein Model Portal is being developed as a module of the Protein Structure Initiative Knowledgebase (PSI KB). The goal of the Models Module is to develop a portal that gives access to the various models that can be leveraged from PSI targets and other experimental protein structures. The Protein Structure Initiative has been successful in determining the structures of many unique proteins in a high throughput manner. Still, the number of known protein sequences is much larger than the number of experimentally solved protein structures. Homology (or comparative) modeling methods make use of experimental protein structures to build models for evolutionary related proteins. Structural genomics and homology modeling thereby complement each other in the exploration of the protein structure space.

For every structure determined by the PSI Centers, hundreds of models can be derived using a variety of established methods. This has been done by all of the PSI centers (CSMP, JCSG, MCSG, NESG, NYSGXRC, JCMM), and by various independent modeling groups (e.g. ModBase, SWISS-MODEL Repository). The Protein Model Portal provides a single interface to query simultaneously the existing precomputed models at various sites, gives access to interactive services for template selection, target-template alignment, model building, and quality assessment.