Website:

http://www.uwstructuralgenomics.org

Description:

CESG creates, evaluates, and optimizes innovative protocols for producing eukaryotic proteins in soluble form, in particular proteins from humans and other vertebrates. CESG refines methods for improving the yield of three-dimensional structures of high-value targets. CESG seeks to improve the efficiency of all stages from target selection-design to three-dimensional structure determination by X-ray crystallography or NMR spectroscopy.

CESG develops technology aimed at improving the success rates to structure of eukaryotic targets chosen to enlarge our knowledge of sequence-fold space relationships (~40% effort), selected for their biomedical importance ~20% effort), or nominated by the scientific community (~20% effort). CESG actively shares its advances with other PSI centers and the biotechnology, pharmaceutical, and academic communities through collaborations, oral presentations, peer-reviewed articles, submissions to public databases and material repositories, and by conducting technology transfer workshops. CESGs Sesame LIMS is made freely available to the public, and is used by one other PSI-2 center.