Website:

http://atcg3d.org/default.aspx

Description:

The work of the Accelerated Technologies Center for Gene to 3D Structure is focused on the development and dissemination of three emerging technologies which are expected to improve the economics of protein structure determination by X-ray crystallographic methods.

Primary technology development initiatives include:

• Computer-aided synthetic gene design and protein construct engineering (Gene Composer)
• Nanovolume microcapillary crystallization methods and devices (CrystalCards and CrystalSlides)
• A tunable laboratory X-ray source (Compact Light Source)

The technologies are being made commercially available to the scientific community through Emerald BioStructures, Greiner BioOne, Lyncean Technologies, and other qualified corporate partners.

The fully developed ATCG3D technologies, together with the other reported membrane protein technology breakthroughs, are being applied by ATCG3D researchers towards the structural determination of human G-Protein Coupled Receptors (GPCRs). The GPCR target processing effort is directed at providing a much better understanding of structural plasticity in the superfamily of medically relevant integral membrane proteins.

ATCG3D Participating Institutions:

Emerald BioStructures, Inc.
http://www.emeraldbiostructures.com/

The Scripps Research Institute 
http://kuhn.scripps.edu/default.aspx

The University of Chicago 
http://ismagilovlab.uchicago.edu

Lyncean Technologies, Inc. 
http://www.lynceantech.com

ATCG3D Investigators:

Lance Stewart, Emerald BioStructures (PI)
Peter Kuhn, The Scripps Research Institute (Co-PI)
Raymond Stevens, The Scripps Research Institute (Co-PI)
Rustem Ismagilov, The University of Chicago (Participating PI)
Ronald Ruth, Lyncean Technologies, Inc. (Participating PI)